{"id":1226,"date":"2014-12-11T08:40:14","date_gmt":"2014-12-11T14:40:14","guid":{"rendered":"http:\/\/www.satirnet.com\/satirnet\/?p=1226"},"modified":"2019-01-27T10:55:59","modified_gmt":"2019-01-27T16:55:59","slug":"toxicologia-laboral-basica","status":"publish","type":"post","link":"https:\/\/www.satirnet.com\/satirnet\/2014\/12\/11\/toxicologia-laboral-basica\/","title":{"rendered":"TOXICOLOG\u00cdA LABORAL BASICA"},"content":{"rendered":"<p>Se define como t\u00f3xico a toda sustancia externa que, al entrar en contacto con el\u00a0organismo, puede provocar una respuesta perjudicial, da\u00f1os serios o, incluso, la muerte.<br \/>\nExisten t\u00f3xicos que pueden ser da\u00f1inos a altas dosis, pero inocuos e, incluso,\u00a0indispensables, a dosis bajas. Por otro lado, pueden afectar a una parte del cuerpo o dar\u00a0lugar a una alteraci\u00f3n generalizada, siendo los cambios temporales, permanentes o\u00a0manifestarse en la descendencia.<\/p>\n<p>El posible efecto nocivo de los contaminantes qu\u00edmicos sobre la salud, debido a su\u00a0presencia en el ambiente laboral, es consecuencia de la acci\u00f3n t\u00f3xica que en general\u00a0pueden ejercer. Se entiende por toxicidad o acci\u00f3n t\u00f3xica la capacidad relativa de una\u00a0sustancia para ocasionar da\u00f1os en los organismos vivos una vez que ha alcanzado un\u00a0punto del cuerpo susceptible a su acci\u00f3n.<\/p>\n<p><!--more--><\/p>\n<p>La acci\u00f3n t\u00f3xica se ejerce mediante modificaciones de las funciones del organismo a\u00a0nivel celular, bioqu\u00edmico 0 molecular, que dar\u00e1n lugar a una manifestaci\u00f3n observable o\u00a0efecto.<br \/>\nLa exposici\u00f3n a un contaminante, entendida como una situaci\u00f3n de contacto efectivo\u00a0del contaminante con el individuo, origina un proceso de interacci\u00f3n mutua:<\/p>\n<p>&#8211; Por un lado, la acci\u00f3n del organismo sobre el contaminante, que se traduce en\u00a0su posible absorci\u00f3n, distribuci\u00f3n, metabolizaci\u00f3n y eliminaci\u00f3n (ADME). Todos\u00a0estos procesos van a determinar la duraci\u00f3n y que se alcance un determinado\u00a0nivel de concentraci\u00f3n del t\u00f3xico en el \u00f3rgano o tejido donde ejerce su acci\u00f3n.<br \/>\n&#8211; Por otro lado, se tiene la acci\u00f3n adversa que pueda desarrollar el contaminante\u00a0sobre el organismo, una vez que ha alcanzado una concentraci\u00f3n determinada\u00a0en dicho \u00f3rgano, por ejemplo, interfiriendo la actividad de algunos enzimas.<\/p>\n<p>Las posibles acciones de un t\u00f3xico en el organismo se ilustran en la figura siguiente:<\/p>\n<p><a href=\"http:\/\/www.satirnet.com\/satirnet\/wp-content\/uploads\/2014\/11\/toxicologico.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-1228\" src=\"http:\/\/www.satirnet.com\/satirnet\/wp-content\/uploads\/2014\/11\/toxicologico.gif\" alt=\"toxicologico\" width=\"684\" height=\"393\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Se define como t\u00f3xico a toda sustancia externa que, al entrar en contacto con el\u00a0organismo, puede provocar una respuesta perjudicial, da\u00f1os serios o, incluso, la muerte. Existen t\u00f3xicos que pueden ser da\u00f1inos a altas dosis, pero inocuos e, incluso,\u00a0indispensables, a dosis bajas&#8230;.<\/p>\n","protected":false},"author":1,"featured_media":1227,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55],"tags":[],"class_list":["post-1226","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-higiene-industrial"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>TOXICOLOG\u00cdA LABORAL BASICA - SatirNet Safety<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.satirnet.com\/satirnet\/2014\/12\/11\/toxicologia-laboral-basica\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TOXICOLOG\u00cdA LABORAL BASICA - SatirNet Safety\" \/>\n<meta property=\"og:description\" content=\"Se define como t\u00f3xico a toda sustancia externa que, al entrar en contacto con el\u00a0organismo, puede provocar una respuesta perjudicial, da\u00f1os serios o, incluso, la muerte. 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